The FDA has always been supportive of this approach of repurposing well established drugs for new indications. In fact they have a regulatory framework called 505(b)(2). There’s a lot of safety advantages but the business end is very nebulous. If hydroxychloroquine had been effective against Covid this would have likely been the path.
Understanding protein binding is necessary and they were among the first applications of any advance in computer technology.
Where's the petri dish thread?
-
Deleted User 89
Re: Where's the petri dish thread?
https://www.technologyreview.com/2021/0 ... -proteome/
DeepMind says it will release the structure of every protein known to science
DeepMind says it will release the structure of every protein known to science
Re: Where's the petri dish thread?
If we didn’t think computational biologists were insufferable already……..
Now every two-bit medicinal chemist is going to believe that every protein is druggable.
Seriously, this is an amazing accomplishment! It would be great to study protein-protein interactions, which I believe is where the future of Biopharmaceutical research is
Now every two-bit medicinal chemist is going to believe that every protein is druggable.
Seriously, this is an amazing accomplishment! It would be great to study protein-protein interactions, which I believe is where the future of Biopharmaceutical research is
-
Deleted User 89
Re: Where's the petri dish thread?
lolzsn wrote: ↑Mon Oct 18, 2021 3:26 pm If we didn’t think computational biologists were insufferable already……..
Now every two-bit medicinal chemist is going to believe that every protein is druggable.
Seriously, this is an amazing accomplishment! It would be great to study protein-protein interactions, which I believe is where the future of Biopharmaceutical research is
i agree, that this is a monumental accomplishment. and yes, now they’ve just got to be able to predict docking interactions (in thinking specifically along the lines of antibodies) and drug discovery will become incredibly streamlined
Re: Where's the petri dish thread?
soo koalas are being vaccinated for chlamydia
Re: Where's the petri dish thread?
Yea, apparently the koalas are some kinda “pro-life” religious types or whatever, cuz they aren’t using condoms either.
-
Deleted User 89
Re: Where's the petri dish thread?
wasted effort, but not necessarily new (i don’t think)
koalas seem to be on their way out. they were already under immense pressure, but the recent massive fires really took a toll
https://www.bbc.com/news/world-australia-53231348
koalas seem to be on their way out. they were already under immense pressure, but the recent massive fires really took a toll
https://www.bbc.com/news/world-australia-53231348
Re: Where's the petri dish thread?
Don't blame the fires bro, that's just what big pharma wants you to believe. They're becoming extinct from the unsafe experimental vaccines. Lobster even knows an athlete who lost his career from a koala vaccine.TraditionKU wrote: ↑Tue Oct 19, 2021 10:19 am wasted effort, but not necessarily new (i don’t think)
koalas seem to be on their way out. they were already under immense pressure, but the recent massive fires really took a toll
https://www.bbc.com/news/world-australia-53231348
I only came to kick some ass...
Rock the fucking house and kick some ass.
Rock the fucking house and kick some ass.
Re: Where's the petri dish thread?
The Koala vaccine makes you peel bananas upside down.
Defense. Rebounds.
Re: Where's the petri dish thread?
BUT MAH RIGHTS
Randy when and where’s the onion eating rally?
Randy when and where’s the onion eating rally?
Re: Where's the petri dish thread?
Mexican diarrhea.
No big deal, it only kills like 500 people per year in the US.
No big deal, it only kills like 500 people per year in the US.
I only came to kick some ass...
Rock the fucking house and kick some ass.
Rock the fucking house and kick some ass.
-
Deleted User 89
Re: Where's the petri dish thread?
https://www.wired.com/story/fungi-clima ... rand=wired
...In 2009, a patient in Japan developed a new fungal infection on their ear. The highly transmissible Candida auris fungus had been previously unknown to science (and resistant to the drugs available to treat it), but within a few years, cases started emerging in Venezuela, Iran, Russia, and South Africa.
Scientists assumed that the spread was due to human travel, but when they sequenced the cases, they were surprised to find that these strains weren’t closely related at all. Instead, scientists were seeing multiple, independent infections of an unknown fungal disease, emerging around the world, all at the same time. About a third of people infected with Candida auris die from the infection within 30 days, and there have now been thousands of cases in 47 countries. Some scientists think this sudden boom in global cases is a harbinger of things to come.
...
Humans can and do get fungal infections (athlete’s foot, for starters, and fungal diseases are one of the leading causes of death for immunocompromised people with HIV). But people are generally unlikely to fall to a fungus for one big reason: humans are hot. (Although, if you want to be the pedant at a party, you might enjoy learning that humans are generally not, in fact, the commonly cited 98.6 degrees Fahrenheit. That number comes from a German study done in 1851. In fact, human body temperature seems to have been cooling recently, and the global average is between 97.5 and 97.9 degrees Fahrenheit.) Warm-blooded environments, in general, tend to be too warm for a fungus to survive. One of Casadevall’s studies estimated that 95 percent of fungal species simply cannot survive at average human internal temperature.
...
TO BE SURE, fungal infections are already more common in warm locations—the rates of a fungus called cryptococcosis, which can be deadly to people with AIDS, can reach 30 percent in Africa, compared to just 5-10 percent in more temperate regions. But there’s still a fine yet crucial line between internal human body temperature and the conditions in tropical environments. For a fungus to live or die, even a few degrees can make all the difference. As the world continues to warm, a growing number of places will approach internal human body temperature more of the time. Sooner or later, the fungi will learn to adapt. And if they do, they might find a whole new set of hosts in us.
This is what Casadevall thinks is happening, at least in part, with the recent surge in Candida auris cases all over the globe. In one study, scientists showed that the fungus is capable of growing and reproducing at higher temperatures than its close relatives. And it might not be the last fungal infection to emerge in our age of climate change—Casadevall estimates that for every 1 degree increase in global temperature, the thermal gradient barrier between our guts and fungi could decrease by 5 percent.
Right now, Casadevall and his colleagues are trying to come up with a list of the most likely fungal species to be able to cross over to humans—species that already live on the threshold of our body temperatures. We’re a long way from having that information, as it’s not even clear which species we need to worry about most, and where those species live...
...In 2009, a patient in Japan developed a new fungal infection on their ear. The highly transmissible Candida auris fungus had been previously unknown to science (and resistant to the drugs available to treat it), but within a few years, cases started emerging in Venezuela, Iran, Russia, and South Africa.
Scientists assumed that the spread was due to human travel, but when they sequenced the cases, they were surprised to find that these strains weren’t closely related at all. Instead, scientists were seeing multiple, independent infections of an unknown fungal disease, emerging around the world, all at the same time. About a third of people infected with Candida auris die from the infection within 30 days, and there have now been thousands of cases in 47 countries. Some scientists think this sudden boom in global cases is a harbinger of things to come.
...
Humans can and do get fungal infections (athlete’s foot, for starters, and fungal diseases are one of the leading causes of death for immunocompromised people with HIV). But people are generally unlikely to fall to a fungus for one big reason: humans are hot. (Although, if you want to be the pedant at a party, you might enjoy learning that humans are generally not, in fact, the commonly cited 98.6 degrees Fahrenheit. That number comes from a German study done in 1851. In fact, human body temperature seems to have been cooling recently, and the global average is between 97.5 and 97.9 degrees Fahrenheit.) Warm-blooded environments, in general, tend to be too warm for a fungus to survive. One of Casadevall’s studies estimated that 95 percent of fungal species simply cannot survive at average human internal temperature.
...
TO BE SURE, fungal infections are already more common in warm locations—the rates of a fungus called cryptococcosis, which can be deadly to people with AIDS, can reach 30 percent in Africa, compared to just 5-10 percent in more temperate regions. But there’s still a fine yet crucial line between internal human body temperature and the conditions in tropical environments. For a fungus to live or die, even a few degrees can make all the difference. As the world continues to warm, a growing number of places will approach internal human body temperature more of the time. Sooner or later, the fungi will learn to adapt. And if they do, they might find a whole new set of hosts in us.
This is what Casadevall thinks is happening, at least in part, with the recent surge in Candida auris cases all over the globe. In one study, scientists showed that the fungus is capable of growing and reproducing at higher temperatures than its close relatives. And it might not be the last fungal infection to emerge in our age of climate change—Casadevall estimates that for every 1 degree increase in global temperature, the thermal gradient barrier between our guts and fungi could decrease by 5 percent.
Right now, Casadevall and his colleagues are trying to come up with a list of the most likely fungal species to be able to cross over to humans—species that already live on the threshold of our body temperatures. We’re a long way from having that information, as it’s not even clear which species we need to worry about most, and where those species live...
Re: Where's the petri dish thread?
So Mich was ahead of the times in warning us about The Fungus? Whodda thunk!
-
Deleted User 89
-
Deleted User 89
Re: Where's the petri dish thread?
This must be the fungus MICH has been talking about?TraditionKU wrote: ↑Mon Nov 29, 2021 1:52 pm tragic story
https://www.sciencenewsdigital.org/scie ... eId1744989
Sad story indeed
-
KUTradition
- Contributor
- Posts: 13876
- Joined: Mon Jan 03, 2022 8:53 am
Re: Where's the petri dish thread?
Have we fallen into a mesmerized state that makes us accept as inevitable that which is inferior or detrimental, as though having lost the will or the vision to demand that which is good?
Re: Where's the petri dish thread?
I represent that image 
