You might not know anything about science, physics, or enginurding, but you're one helluva judge of medical expertise!
#idbehonored
Shrooms
Re: Shrooms
#idbehonored
"Conservatism consists of exactly one proposition, to wit: There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect."
Frank Wilhoit
Frank Wilhoit
Re: Shrooms
I should warn you that there will be a thorough vetting process before anything is made official. But if you have ever been accused of domestic battery, put that on your resume as I will consider that a yuge plus.
Nero is an angler in the lake of darkness
Re: Shrooms
Time for you to start a YouTube channel, Shirls.
Re: Shrooms
Get a room.
Do not go gentle into that good night, Old age should burn and rave at close of day; Rage, rage against the dying of the light.
Re: Shrooms
You must be confused, Shirley has been banned from this site since it was started.
Guess she wasn't willing to fuck her way in?
"Conservatism consists of exactly one proposition, to wit: There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect."
Frank Wilhoit
Frank Wilhoit
Re: Shrooms
Good question.
Some people say several emails were sent to the powers that be back then, but were never answered.
#shrug
"Conservatism consists of exactly one proposition, to wit: There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect."
Frank Wilhoit
Frank Wilhoit
Re: Shrooms
Single dose of LSD provides immediate and lasting relief from anxiety, study says
A clinical trial’s encouraging results won US Food and Drug Administration breakthrough therapy status for an LSD formulation to treat generalized anxiety disorder, Mind Medicine Inc. announced Thursday. The biopharmaceutical company is developing the drug.
“A breakthrough designation is a recognition that a drug has demonstrated evidence of clinical efficacy in meeting an unmet medical need with morbidity and mortality associated with it,” said Dr. Daniel Karlin, assistant professor of psychiatry at Tufts University School of Medicine in Boston and chief medical officer for MindMed.
MindMed’s MM120 will still go through the standard FDA approval process, including phase III trials.
...A single dose of MM120 (lysergide d-tartrate) led to a 48% rate of remission from generalized anxiety disorder at 12 weeks following the drug’s administration, according to MindMed.
The MM120 drug also significantly improved clinical signs of generalized anxiety disorder for 65% of patients within three months, according to results of the phase 2b trial designed to test dosage levels, the company said.
Anxiety is the most common mental disorder in the United States, affecting over 40 million people age 18 and older each year, according to the Anxiety and Depression Association of America. Generalized anxiety order is characterized by excessive, ongoing thoughts that are difficult to control and interfere with day-to-day activities.
“The clinical improvement for many patients was more than double what we see with today’s standard of care,” Karlin said. “This occurred at all levels of anxiety, from moderate all the way up to severe.”
...Compared with experiences with forms of LSD purchased illegally on the street, the study’s grade of MM120 did not appear to induce “bad trips,” Karlin said.
“LSD is difficult to manufacture with high purity and tends to degrade quickly in the presence of light and water,” Karlin said. “We’re manufacturing it to pharmaceutical industry standards, a highly pure version that is also shelf stable. So that’s a critical difference.”
A long history of LSD research
When the MM120 clinical trial began in August 2022, it marked the first time LSD had been studied in a medical setting in over 40 years, Karlin said.
During the 1940s and early 1950s, tens of thousands of patients took LSD and other psychotropics to study their effects on cancer anxiety, alcoholism, opioid use disorder, depression, and post-traumatic stress disorder or PTSD. Researchers began to see psychedelics as possible “new tools for shortening psychotherapy.”
But when Harvard University psychologists Timothy Leary and Richard Alpert were fired from the Harvard Psilocybin Project in 1963 after the university discovered they had been giving LSD to their students, the use of psychedelics for research began to lose its luster.
[...]
A clinical trial’s encouraging results won US Food and Drug Administration breakthrough therapy status for an LSD formulation to treat generalized anxiety disorder, Mind Medicine Inc. announced Thursday. The biopharmaceutical company is developing the drug.
“A breakthrough designation is a recognition that a drug has demonstrated evidence of clinical efficacy in meeting an unmet medical need with morbidity and mortality associated with it,” said Dr. Daniel Karlin, assistant professor of psychiatry at Tufts University School of Medicine in Boston and chief medical officer for MindMed.
MindMed’s MM120 will still go through the standard FDA approval process, including phase III trials.
...A single dose of MM120 (lysergide d-tartrate) led to a 48% rate of remission from generalized anxiety disorder at 12 weeks following the drug’s administration, according to MindMed.
The MM120 drug also significantly improved clinical signs of generalized anxiety disorder for 65% of patients within three months, according to results of the phase 2b trial designed to test dosage levels, the company said.
Anxiety is the most common mental disorder in the United States, affecting over 40 million people age 18 and older each year, according to the Anxiety and Depression Association of America. Generalized anxiety order is characterized by excessive, ongoing thoughts that are difficult to control and interfere with day-to-day activities.
“The clinical improvement for many patients was more than double what we see with today’s standard of care,” Karlin said. “This occurred at all levels of anxiety, from moderate all the way up to severe.”
...Compared with experiences with forms of LSD purchased illegally on the street, the study’s grade of MM120 did not appear to induce “bad trips,” Karlin said.
“LSD is difficult to manufacture with high purity and tends to degrade quickly in the presence of light and water,” Karlin said. “We’re manufacturing it to pharmaceutical industry standards, a highly pure version that is also shelf stable. So that’s a critical difference.”
A long history of LSD research
When the MM120 clinical trial began in August 2022, it marked the first time LSD had been studied in a medical setting in over 40 years, Karlin said.
During the 1940s and early 1950s, tens of thousands of patients took LSD and other psychotropics to study their effects on cancer anxiety, alcoholism, opioid use disorder, depression, and post-traumatic stress disorder or PTSD. Researchers began to see psychedelics as possible “new tools for shortening psychotherapy.”
But when Harvard University psychologists Timothy Leary and Richard Alpert were fired from the Harvard Psilocybin Project in 1963 after the university discovered they had been giving LSD to their students, the use of psychedelics for research began to lose its luster.
[...]
"Conservatism consists of exactly one proposition, to wit: There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect."
Frank Wilhoit
Frank Wilhoit
Re: Shrooms
Thanks for this post. I find it positive that clinical research of psychedelics is progressing and the FDA is promoting.
Same concept with the current ketamine therapy trend.
Back in late 90's we'd go to the dance club, roll for hours on mdma, careen home around 4 am and line up the K.
To me, there is no better ego death possible. If you've experienced the K-hole, you understand the gravity.
Ultimately, all those chemicals wrecked my serotonin receptors. I'm paying the price now.
Same concept with the current ketamine therapy trend.
Back in late 90's we'd go to the dance club, roll for hours on mdma, careen home around 4 am and line up the K.
To me, there is no better ego death possible. If you've experienced the K-hole, you understand the gravity.
Ultimately, all those chemicals wrecked my serotonin receptors. I'm paying the price now.
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randylahey
- Posts: 8970
- Joined: Tue Sep 18, 2018 6:13 pm
Re: Shrooms
The world would be a better place if we all microdosed daily
Re: Shrooms
Good thread bump!
I still think harnessing the potential of psychedelics is the best chance humanity has left for ourselves. Always was.
I’m torn between whether it would be better to microdose daily or to completely melt yer face with a good hard trip like a few times a year.
I still think harnessing the potential of psychedelics is the best chance humanity has left for ourselves. Always was.
I’m torn between whether it would be better to microdose daily or to completely melt yer face with a good hard trip like a few times a year.
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RainbowsandUnicorns
- Contributor
- Posts: 12504
- Joined: Fri Oct 29, 2021 8:19 am
Re: Shrooms
Blah blah blah blah blah.
My guess is 90% of those who have taken "psychedelics" will advocate for the benefits of more people to take "psychedelics".
My guess is 90% of those who have not taken "psychedelics" will be critical of the "use" of "psychedelics".
As someone who has taken/eaten shrooms. I fall in the 10% of my first claim.
I have NO doubt SOME people actually benefit from taking/eating "psychedelics" but I have A LOT of doubt as many people who THINK they benefit from taking/eating "psychedelics" actually do benefit from taking/eating "psychedelics".
Trust/believe me when I say, I have SEEN some people who are really fucked up in a NEGATIVE way because they took "psychedelics".
My guess is 90% of those who have taken "psychedelics" will advocate for the benefits of more people to take "psychedelics".
My guess is 90% of those who have not taken "psychedelics" will be critical of the "use" of "psychedelics".
As someone who has taken/eaten shrooms. I fall in the 10% of my first claim.
I have NO doubt SOME people actually benefit from taking/eating "psychedelics" but I have A LOT of doubt as many people who THINK they benefit from taking/eating "psychedelics" actually do benefit from taking/eating "psychedelics".
Trust/believe me when I say, I have SEEN some people who are really fucked up in a NEGATIVE way because they took "psychedelics".
Gutter wrote: Fri Nov 8th 2:16pm
New President - New Gutter. I am going to pledge my allegiance to Donald J. Trump and for the next 4 years I am going to be an even bigger asshole than I already am.
New President - New Gutter. I am going to pledge my allegiance to Donald J. Trump and for the next 4 years I am going to be an even bigger asshole than I already am.
Re: Shrooms
Oh, for sure, gutter.
I think a big thing to consider is psychedelics culturally and legally. We’ve pretty exclusively known them as some illicit counterculture thing. So of course they’re gonna be used/abused in some stoopid ways. And yeah everyone can react differently either way. (And many people are already goofy enough without them.)
I think the potential lies in some more prescribed or structured or mindful way. Let’s try using them therapeutically, maybe under the supervision of, shall we say, mental health professionals (what previous generations might call shamans or medicine men or something, but more legit yet).
The first time I tried acid my biggest takeaway was, holy shit this is the ultimate ADD medicine. Way better than adderrall! And I ended up doing arts and crafts for hours, without running around distracted about everything like I usually am, even on otherwise-legit ADD drugs.
I mean, considering the risk for abuse that legal drugs like adderrall or oxy or even booze can bring, shit like shrooms or lsd almost seems tame. Except they’re still powerful shit that can and will fuck with you. It’s a matter of trying to harness the potential of that fuckery in a positive way - both for the improvement of individual mental health, and greater societal health at large.
Meh, fuck it, I prob sound like even more of a hippie idiot than normal. Now who wants to quit our jobs and go on Phish tour?!
I think a big thing to consider is psychedelics culturally and legally. We’ve pretty exclusively known them as some illicit counterculture thing. So of course they’re gonna be used/abused in some stoopid ways. And yeah everyone can react differently either way. (And many people are already goofy enough without them.)
I think the potential lies in some more prescribed or structured or mindful way. Let’s try using them therapeutically, maybe under the supervision of, shall we say, mental health professionals (what previous generations might call shamans or medicine men or something, but more legit yet).
The first time I tried acid my biggest takeaway was, holy shit this is the ultimate ADD medicine. Way better than adderrall! And I ended up doing arts and crafts for hours, without running around distracted about everything like I usually am, even on otherwise-legit ADD drugs.
I mean, considering the risk for abuse that legal drugs like adderrall or oxy or even booze can bring, shit like shrooms or lsd almost seems tame. Except they’re still powerful shit that can and will fuck with you. It’s a matter of trying to harness the potential of that fuckery in a positive way - both for the improvement of individual mental health, and greater societal health at large.
Meh, fuck it, I prob sound like even more of a hippie idiot than normal. Now who wants to quit our jobs and go on Phish tour?!
Re: Shrooms
There’s a docuseries on one of the streaming services about psychedelics, with an episode about each of the more familiar ones.
The one about MDMA talks about how it was invented in the 40s, and showed massive potential as a therapy drug - effectively treating depression, ptsd, couples therapy, etc, and not only treating but even “curing,” creating lasting/permanent improvements with as little as one prescribed dose.
The series then says the pharmaceutical industry was outraged, cuz how is shareholder wealth supposed to be created with just one dose?! The real money is not in the one-time cure, it’s in the ongoing treatment! They want drugs that can be prescribed on a forever basis, so they can keep selling more drugs! The end game of for-profit medicine is not curing ailments, it’s creating lifetime customers. So big pharma lobbied to have MDMA outlawed instead…Allsome.
The one about MDMA talks about how it was invented in the 40s, and showed massive potential as a therapy drug - effectively treating depression, ptsd, couples therapy, etc, and not only treating but even “curing,” creating lasting/permanent improvements with as little as one prescribed dose.
The series then says the pharmaceutical industry was outraged, cuz how is shareholder wealth supposed to be created with just one dose?! The real money is not in the one-time cure, it’s in the ongoing treatment! They want drugs that can be prescribed on a forever basis, so they can keep selling more drugs! The end game of for-profit medicine is not curing ailments, it’s creating lifetime customers. So big pharma lobbied to have MDMA outlawed instead…Allsome.
Re: Shrooms
Also didn’t 1985 have some theory like this, that there’s cures for cancer but the money’s in the treatment instead?
Re: Shrooms
Perhaps. For what's worth, 85 passed away from lung cancer. He was a heavy smoker like many of us were in college and after. His was in remission for awhile.
But now the corporate evil bastards are marketing pouches such as ON and Zyn. Even more addictive and cause oral degradation and cancer.
The next healthcare grift trend will be private equity-owned jaw reconstruction surgery centers for nicotine pouch addicts.
Re: Shrooms
according to the latest dental studies the nicotine pouches, while definetelt addictive, are not thought to cause oral cancer.thebones wrote: ↑Thu Mar 21, 2024 9:30 pmPerhaps. For what's worth, 85 passed away from lung cancer. He was a heavy smoker like many of us were in college and after. His was in remission for awhile.
But now the corporate evil bastards are marketing pouches such as ON and Zyn. Even more addictive and cause oral degradation and cancer.
The next healthcare grift trend will be private equity-owned jaw reconstruction surgery centers for nicotine pouch addicts.
Just Ledoux it
Re: Shrooms
Yes, the same as the apocryphal 100 mpg carburetor.
I’m reminded of a comment my retina-surgeon made about 10 years ago. He’s around my age and a really fun guy to talk to. We always shoot the breeze after my appointment, which is, for that reason the last one of the day.
This was when California had passed medical marijuana and one could get it with a prescription. I have a propensity for high intraocular pressure thus putting me at risk of glaucoma, something smoking pot likely relieved. Various drugs and psychedelics came up in conversation. His point really resonated with me, especially as someone who works in the pharmaceutical industry. He said he’ll give me a prescription for marijuana if I wanted to smoke it, but don’t ask him to do it for therapeutic reasons. He said that are much more reliable, long lasting and effective medicines for lowering eye pressure. I’ve been on drops for more than a decade with lasting success.
Pharmaceuticals have been optimized to deliver effective doses at safe levels, a condition for approval.